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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically focused on the practical aspects of study design, such as the recruitment and consent process, adherence, and the use of standard equipment.

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A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for a pragmatic trial to be reliable and to reduce bias in the results, is also necessary. However too much heterogeneity could lead to problems with the design of the trial.

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The aim of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. Usually, they are commissioned by policymakers and 프라그마틱 슬롯 체험 practitioners in order to inform their decisions. They can also be used to assess the causal relationship between an intervention with its outcomes. However, they should not be used to replace the need for explanation studies.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial that include the recruitment process, the design and delivery of the intervention, as well as follow-up.

There is a positive trend in the number of pragmatic trials published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary-care settings.