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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of study design, such as recruitment and consent in adherence, as well as the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographic areas. This type of heterogeneity, that is crucial for a pragmatic trial to be valid and lessen the chance of bias is also essential. However, too much heterogeneity could cause issues with the trial design.

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The aim of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. They are usually commissioned by policymakers and practitioners to help guide their decisions. They can be used to determine the causal relationship between an intervention and 프라그마틱 무료체험 its results. However, they should not be used to replace explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the features of a practical trial that include the recruitment process, the design and implementation of the intervention, and the follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.