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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of design which include recruitment and consent, adherence and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographical regions. This type of heterogeneity that is crucial for 프라그마틱 무료스핀 a pragmatic trial to be valid and reduce bias in results, is also necessary. However, too much heterogeneity can cause problems with the design of the trial.

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The aim of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. They are typically requested by practitioners and policymakers to inform their decisions. They can also be used to determine the causality of an intervention and its effects. However, they should not be used in lieu for the use of explanation trials.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the elements of a pragmatic study which includes the recruitment, design, and delivery of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the subject of pragmatism. It is important to keep in mind that the majority were conducted in primary-care settings.